Our Research & Expertise

Go to Chronic Kidney Disease

Chronic Kidney Disease

We are studying the mechanism of kidney injury and repair with the ultimative goal to find new treatments for the vast and growing patient population suffering from chronic kidney disease (CKD).

Go to Heart Failure

Heart Failure

Chronic heart failure is the leading hospital discharge diagnose and the killer of patients with chronic kidney disease. We are studying key signaling pathways between pericytes, cardiomyocytes and endothelial cells to develop novel therapeutics in heart failure and uremic cardiomyopathy.

Go to Fibrosis

Fibrosis

Fibrosis has been estimated to be involved in almost 50% of all deaths in the developed world. We are studying fibrosis of heart, kidney, lung, vasculature and bone-marrow with the goal to develop novel targeted therapeutics.

Go to Vascular Disease

Vascular Disease

We are performing state of the art genetic fate tracing and omics research to understand the key cellular and molecular events in athero- and arteriosclerosis with a special focus on vulnerable patients with chronic kidney disease and / or diabetes.

CRISPR/Cas9 gene editing

We use in vitro and in vivo CRISPR/Cas9 gene editing to validate pathways and therapeutic targets.

3D cell-culture modeling & Stem Cells

We are working with 3D cell culture models of human and mouse cells for disease modeling, target validation and compound screening.

In vivo studies & translation

We are using various transgenic mouse models for disease modeling and genetic fate tracing and validate findings in human tissue and serum.

Transcriptomics & Proteomics

We are performing state of the art transcriptomics and proteomics to identify novel druggable targets.

OUR TEAM

Rafael Kramann, MD

Principal Investigator
Dr. Kramann is nephrologist and physician scientist and directs the laboratory.

Christoph Kuppe, MD

Postdoctoral Fellow
Christoph is a physician scientist. His research focuses on mechanisms of organ fibrosis, roles of nuclear receptors and identification of novel therapeutic targets.

Nadine Kaesler, PhD

Postdoctoral Fellow
Nadine is trained in nutritional sciences and has >7 years of basic science research experience. Her research focusses on cardiovascular disease in chronic kidney disease with a special interest on vascular calcification and uremic cardiomyopathy.

Judith Schimpf, MD

Postdoctoral Fellow
Judith is a trained physician and currently nephrology fellow. Her research focusses on the mechanism of cardiac hypertrophy in chronic kidney disease.

Sylvia Menzel, BSc (Hons)

Research Associate
Sylvia is a trained biologist with >10 years of research experience in basic science and animal models of kidney disease. Her research focusses on mechanism of kidney injury and repair with a special interest in identification of novel targets in kidney fibrosis.

Nazanin Kabgani, PhD

Postdoctoral Fellow
Nazanin studied biotechnological engineering and received a PhD in Nephrology research. Her work in the lab focusses on 3D printing and modeling of organ fibrosis in the dish.

Susanne Ziegler, PhD

Postdoc / Staff Scientist
Susanne is a trained PhD with a strong background in hematology research and molecular biology. Her work is focussed on gene editing and molecular biology.

Peggy Jirak

Research Technician
Peggy is a research technician with over 10 years of lab experience. She has a strong background in proteomics and kidney disease research.

Imma-Katrin Härthe

Research Technician
Katrin is a chemical technician by training with a longstanding background (>15 years) in basic science and vascular calcification research.

Nina Graff

Research Technician
Nina is a research technician with a background in hematology & oncology research.

Suresh Kaushik, PhD

Postdoctoral Fellow
Suresh has a strong background in molecular biology and pluripotent stem cells. His current projects are focussing on cardiac fibrosis and regeneration.

Konrad Hoeft

Graduate Student
Konrad is interested in iron metabolism triggering inflammation in chronic kidney disease and identification of novel druggable targets for kidney fibrosis.

Yaoxian (Jack) Xu, MSc

Graduate Student
Jack has a strong background in cancer research and gene editing. His work in the lab is focussing on organoids, stem cells and CRISPR/Cas9 gene editing.

Flavia Ribezzo

Graduate Student
Flavia studied biology and her PhD thesis is focussed on the role of inflammation and chronic kidney disease on the bone marrow environment and HSC differentiation. She is co-supervised by Prof. Schneider (Erasmus MC).

Join our Team

We are continously looking for talented postdocs and PhD students with a strong background in molecular biology and flow cytometry. If you are interested please send your CV and a letter of intent to Dr. Kramann rkramann@gmx.net

Recent Work

selected publications from the lab

If you are interested in supporting our research by donation and help to develop novel therapeutics for the vast and growing population of patients suffering from organ fibrosis, heart failure and chronic kidney disease you can contact Dr. Kramann via email

LATEST NEWS FROM THE LAB

ERC Funding for Kramann Lab

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Open position for a postdoc with a strong background in molecular biology & cloning

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